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Endothelial Cell Mechanosensitivity - from Large Arteries to the Microcirculation


会場青葉山キャンパス 医工学研究科 ナノ医工学研究棟 講堂
Dr. Roland Kaunas
(Ph.D., Assistant Professor, Department of Biomedical Engineering, Texas A&M University)

Endothelial Cell Mechanosensitivity - from Large Arteries to the Microcirculation

Endothelial cells lining blood vessels are exceptionally sensitive to the mechanical forces generated by blood flow and pressure. In most regions of the large arteries, fluid shear stress and cyclic stretching of the vessel wall induce axial alignment of the endothelial cells. The unique mechanical environment at arterial branches and curvatures inhibit endothelial alignment and promote a dysfunctional endothelial phenotype conducive to the development of atherosclerotic plaques. Integrated experimental and theoretical modeling studies will be discussed that have revealed a dynamic relationship between the temporal patterns of matrix deformation, actin cytoskeletal reorganization and signal transduction. In particular, these studies indicate non-muscle myosin II plays a pivotal role in allowing endothelial cells to adapt to their mechanical environment to maintain tensional and functional homeostasis.

Angiogenesis occurring in the microvasculature is also regulated by the local mechanical environment. It has long been recognized that fluid forces can stimulate microvascular growth, but little attention has been directed toward understanding the underlying mechanisms. To initiate angiogenesis, endothelial cells must be first induced to invade into the underlying extracellular matrix. Results from recent experiments exploring the molecular pathways regulating flow-induced endothelial cell invasion into extracellular matrices will be discussed.
問い合わせ先GCOE事務局 Tel: 022-795-7005

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