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70th NanoBME Series Seminar
Histotripsy: Controlled Mechanical Sub-Division of Soft Tissues by High Intensity Pulsed Ultrasound
Place: 2F Seminar Room, Graduate School of Biomedical Engineering Nano-Biomedical Engineering Research Laboratory
| Date | Monday 26 March 2012 15:00-16:30 |
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| Place | 2F Seminar Room, Graduate School of Biomedical Engineering Nano-Biomedical Engineering Research Laboratory |
| Outline |
(Department of Biomedical Engineering, University of Michigan, Ann Arbor) "Histotripsy: Controlled Mechanical Sub-Division of Soft Tissues by High Intensity Pulsed Ultrasound" Histotripsy is a non-invasive image guided surgical modality based on generation of energetic localized bubble clouds with short pulses of focused very high intensity ultrasound. The mechanism of tissue destruction is purely mechanical and non-thermal. Because the bubbles are localized within a supra-threshold region, and individual bubbles are quite small, the lesions are highly localized. Transition zones from completely homogenized tissue to unaffected tissue are often only microns wide. Because the bubble clouds are easily seen on diagnostic ultrasound images, visible bubble clouds confirm the lesioning process and its location. Moreover, since the energetic bubbles (“micro-scalpels”) result in progressively more mechanical fractionation of the tissue, eventually no structures large enough to scatter ultrasound remain and the treated region becomes very hypoechoic and easily identified. The reduction in backscatter is proportional to tissue damage and provides a quantitative measure of likely clinical outcome. Because of the thresholding nonlinear nature of bubble cloud generation, the method is relatively insensitive to acoustic aberrations producing clean well defined lesions even through complex intervening tissue. Because the thresholds for cavitation in the therapy volume can be modulated acoustically, active beam sharpening and active protection of critical structures is possible, a process analogous to a non-invasive “cooling modality” in thermal therapy. |
| Contact | GCOE secretariat Tel: 022-795-7005 |
